Ashwagandha: Benefits and Side Effects

Used for thousands of years in Ayurvedic medicine, ashwagandha (Withania somnifera), also known as Indian ginseng, is now one of the most studied and popular medicinal plants in natural dietary supplements.

Known for its adaptogenic properties, it helps the body adapt to stress, restore physical and mental balance, and strengthen its defenses against attacks. Its powerful roots, rich in withanolides, contain most of its active compounds with anti-inflammatory, antioxidant, and neuroprotective effects.

In a context where chronic stress, mental fatigue, and sleep disorders are becoming common concerns, ashwagandha is emerging as a serious natural solution, at the crossroads between tradition and modern science.

In this article, we will explore:

  • The origin and ancestral use of this adaptogenic plant
  • Its scientifically validated benefits (stress, cognition, immunity, etc.)
  • The existing forms (roots, extracts, KSM-66, etc.)
  • The recommended dosages and precautions to be aware of

Whether you are a fan of alternative medicine, looking for solutions to better manage stress, or simply curious about incorporating a natural dietary supplement into your routine, this article will give you a better understanding of all that ashwagandha can do for you.

Ashwagandha - Sommaire

Summary

  1. 1.Origin and history of ashwagandha
  2. 2.The benefits of ashwagandha
  3. 3.How to use ashwagandha?
  4. 4.Recommended dosage
  5. 5.Side effects
  6. 6.Key takeaways

Origin and history of ashwagandha

Ashwagandha (Withania somnifera Dunal) is a plant native to the arid regions of India, the Middle East, and parts of North Africa. It belongs to the Solanaceae family, which also includes tomatoes, eggplants, and belladonna.

In Sanskrit, its name literally means “horse smell” (ashwa = horse, gandha = smell), a reference both to the strong aroma of its roots and their supposed ability to impart strength and vitality, “like that of a horse.”

Origine et histoire de l'ashwagandha

A sacred plant in Ayurvedic medicine

Ashwagandha is one of the most renowned plants in Ayurveda, an ancient medical system practiced in India for over 3,000 years. It is classified as Rasayana, meaning a plant that:

  • Strengthens the body and mind
  • Promotes longevity
  • Supports reproductive and mental functions
  • Helps restore dosha balance, especially in cases of excess Vata

Traditionally, Ayurvedic practitioners used the dried roots in decoctions, powders, or mixed with ghee (clarified butter) and honey, particularly in men to increase endurance, stress resistance, sexual vigor, and memory.

A recent resurgence of scientific interest

Although this medicinal plant has been used for thousands of years, it is only recently that modern research has focused on its active compounds and mechanisms of action. Ashwagandha is now the subject of numerous clinical studies to evaluate its effectiveness in areas such as:

  • Chronic stress and cortisol management
  • Mild anxiety disorders
  • Mental or physical fatigue
  • Cognitive and athletic performance
  • Support for male fertility

This combination of tradition and science explains its growing success in natural dietary supplements, particularly among people who are concerned about their overall well-being and do not want to rely systematically on synthetic molecules.

Bienfaits de l'ashwagandha

The benefits of ashwagandha (Withania somnifera)

Relief from stress, anxiety, and cortisol regulation

Ashwagandha is widely recognized for its adaptogenic effects, enabling the body to better manage chronic stress and alleviate anxiety. Several double-blind clinical trials have shown significant reductions in perceived stress scores and levels of cortisol, the stress hormone.

  • A randomized trial showed a notable decrease in cortisol and stress scores after 60 days of supplementation (300 mg, twice daily) (1).
  • A 90-day study with an extended-release formulation also revealed improvements in sleep quality, concentration, and psychological well-being, while reducing cortisol (2).
  • A systematic review indicates that ashwagandha can alleviate anxiety, stress, and fatigue symptoms, with significant effects on anxiety disorders (3).

Another recent clinical study confirmed a reduction in salivary cortisol and an improvement in overall well-being with a standardized extract containing 2.5% withanolides (5).

Cognitive effects and improved concentration

Ashwagandha may also support cognitive function:

  • A meta-analysis highlights improvements in executive function, attention, and reaction time in adults with mild cognitive impairment or psychiatric disorders (3).

  • A study using an SR (sustained release) capsule showed improved memory and concentration after 90 days of supplementation (2).

Immune system support, physical performance, and hormonal balance

  • Some data from Ayurvedic medicine and modern research suggest that ashwagandha has antioxidant, anti-inflammatory, and immunomodulatory properties (6).
  • Pilot studies show improved physical endurance and muscle recovery in athletes (7).
  • In men, ashwagandha supplementation has been associated with increased testosterone levels and improved sexual vitality and physical strength (7).
Références scientifiques
  1. Chandrasekhar K. et al. (2012). A prospective, randomized double-blind placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Withania somnifera in reducing stress and anxiety in adults. Indian J Psychol Med. PMC3573577

  2. Gopukumar K. et al. (2021). Evaluation of the efficacy of Ashwagandha root extract capsules SR in improving memory and sleep in adults. J of Ayurveda and Integrative Medicine. PMC8632422

  3. Ng QX et al. (2020). A Systematic Review and Meta-Analysis of the Effect of Ashwagandha on Anxiety. Journal of Anxiety Disorders. PubMed:31742775

  4. Lopresti AL et al. (2019). Adaptogenic activity of Withania somnifera: a systematic review. American Journal of Men’s Health. DOI:10.1177/1557988319835985

  5. Majeed M. et al. (2023). A standardized ashwagandha root extract alleviates stress and cortisol levels. Medicine (Baltimore). DOI:10.1097/MD.0000000000032005

  6. Withania somnifera Wikipedia + meta-analyses sur les propriétés antioxydantes et immunitaires. Wikipedia EN

  7. Études diverses sur la performance physique, testostérone et récupération. Résumé dans es.wikipedia.org

How to use ashwagandha?

Ashwagandha is now commercially available in several forms, with varying qualities and concentrations depending on the extracts used. Before detailing the available options, it is useful to understand how the quality of the extract affects its effectiveness.

KSM-66, Sensoril... not all ashwagandhas are created equal.

Not all ashwagandha powders are the same. Some contain simply ground roots, while others contain standardized extracts that are more concentrated in active ingredients called withanolides (the bioactive molecules responsible for anti-stress and adaptogenic effects).

Among the most studied extracts are:

  • KSM-66®: a patented extract derived exclusively from roots (without leaves), obtained through a water and milk extraction process, and standardized to 5% withanolides. It is recognized for its comprehensive adaptogenic profile without sedative effects. Several clinical studies have been conducted specifically on KSM-66, with solid results on stress, endurance, libido, and cognitive performance (1)(2).

  • Sensoril®: another standardized extract, this time with 10% withanolides, but derived from a mixture of roots and leaves. It is often more sedative and is more suitable for people who are very anxious or suffer from insomnia.

💡 Good to know: the type of extract chosen directly influences the effect felt. A KSM-66-based product is ideal for people looking to manage their stress while remaining active and focused — this is the type of extract we have selected for our Ashwa Premium Organic formula (60 capsules — certified organic KSM-66® extract bio).

The different forms of ashwagandha

Raw powder

Dried ashwagandha root can be consumed in powder form. This is the traditional form, but its very bitter taste, dusty texture, and uncertainty in terms of withanolide dosage make it impractical and less reliable.

Extract in capsules

This is the most commonly used form in dietary supplements. It allows for precise dosing, higher concentrations of active ingredients, and better preservation. High-quality products indicate the percentage of withanolides (5%, 10%, etc.) as well as the origin of the extracts (root or leaf). This is the case for the KSM-66® and Sensoril® extracts mentioned above.

Herbal tea or decoction

In Ayurvedic tradition, ashwagandha was often consumed as a decoction (root boiled in milk or water, sometimes with ghee). This practice continues, particularly in India, but remains little used in Europe due to the complexity of preparation and the strong taste.

Liquid forms or gummies

Ashwagandha is also available in the form of mother tinctures, drops, or chewable gummies. These forms are often easier to take for children or adults who are reluctant to take capsules, but the concentration of withanolides is generally much lower than in standardized extracts.

Aliments riche en Magnésium

Recommended dosage

The dosage of ashwagandha depends greatly on the form used, the concentration of active ingredients (particularly withanolides), and the desired outcome: stress, cognitive performance, immunity, recovery, vitality, etc.

Forms of ashwagandha and their concentration

Raw root powder (non-standardized): 1,000 to 5,000 mg/day

→ Low concentration of withanolides (0.2 to 0.5% on average)

→ Less commonly used in modern supplementation

Extract standardized to 2.5%–5% withanolides: 300 to 600 mg/day

→ Most studied and used form in clinical trials

Ultra-concentrated extracts (10% and above): 100 to 300 mg/day

→ To be dosed with caution; fewer studies available on long-term tolerance

Recommended dosages according to objectives

Objective

ObjectiveDosage recommandé (extrait 5% withanolides) Etudes cliniques de référence
Réduction du stress/anxiété250 à 600 mg/jourChandrasekhar e al. 2012 (1)
Amélioration du sommeil300 à 600 mg/jourLangade et al., 2019 (2)
Performance cognitive300 à 500 mg/jourLopresti et al., 2019 (4)
Augmentation de la force et de la masse musculaire300 à 600 mg/jourWankhede et al., 2015 (5)
Soutien immunitaire et vitalité300 à 500 mg/jourAuddy et al., 2008 (7)

These dosages are based on standardized extracts containing approximately 5% withanolides.

Dosage and method of administration

Ideal time: In the morning (for fatigue or cognitive performance) or in the evening (for anxiety or sleep disorders).

With or without food? Preferably with food to improve the absorption of lipophilic active ingredients.

Duration of treatment: Clinical studies have generally been conducted over periods of 8 to 12 weeks. Breaks of 1 to 2 weeks every 2-3 months are recommended for prolonged treatment.

Maximum dose and safety

The EFSA (European Food Safety Authority) has not yet defined a maximum regulatory dose for ashwagandha.

However, most clinical trials do not exceed 1,000 mg/day of standardized extract, even for the most pronounced effects.

In the absence of any medical condition or drug treatment, taking 300 to 600 mg/day of a high-quality extract is generally well tolerated.

Side effects

Although ashwagandha is generally well tolerated, certain precautions should be taken when using it. Like any medicinal plant with powerful effects, it can cause interactions or adverse effects in certain situations.

Possible side effects

Most clinical trials report excellent tolerance of ashwagandha (1)(2), but mild and transient side effects have sometimes been observed:

  • Mild digestive problems (nausea, bloating)
  • Drowsiness or sedation (especially when taken in the morning)
  • Headaches
  • Accelerated intestinal transit

These effects generally occur at high doses (> 800 mg/day) or in highly sensitive individuals. The form used (standardized extract vs. raw powder) also plays a role in tolerance.

Drug interactions

Ashwagandha may potentiate or interact with certain medications. It should therefore be used with caution (and under medical supervision) in the following cases:

  • Sedative or anxiolytic treatments (benzodiazepines, antihistamines, etc.)

→ Risk of excessive sedation

  • Thyroid medications (levothyroxine)

→ Ashwagandha may slightly stimulate thyroid function (3)

  • Immunosuppressants

→ Risk of reduced therapeutic effect

  • Hormone treatments or chemotherapy

→ Always seek medical advice

Contraindications

The French National Health Security Agency (Anses) recommends avoiding ashwagandha in the following situations:

  • Pregnancy and breastfeeding: contraindicated (theoretical risk of uterine stimulation)
  • Confirmed or unstable hyperthyroidism
  • History of hormone-dependent cancer (e.g., breast or prostate cancer)
  • Children under 12 years of age: not recommended

Ashwagandha banned in France: true or false?

No, ashwagandha is not banned in France, but it is regulated.

Ashwagandha is on the list of plants authorized for use in dietary supplements in France.

☝️Key takeaways

Used for thousands of years in Ayurvedic medicine, ashwagandha (Withania somnifera) has stood the test of time without losing any of its relevance. Today, modern science confirms many of its adaptogenic properties and benefits for stress, cognitive performance, physical vitality, and even the immune system.

Thanks to its rich bioactive compounds, particularly withanolides, this medicinal plant offers overall support for the body and is well tolerated when used correctly.

However, like any dietary supplement, ashwagandha should be taken with caution: it is important to follow the recommended doses, choose high-quality standardized extracts, and consult a healthcare professional if you have any doubts or pre-existing conditions.

Whether you are looking to reduce stress, regain energy, or support your mental functions, ashwagandha could well become a natural ally for your everyday well-being.

Our dietary supplements containing Ashwagandha